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:: Volume 12, Issue 4 (suppl1 2011) ::
J Shahrekord Univ Med Sci 2011, 12(4): 62-69 Back to browse issues page
Effect of Achillea millefolium, Artemisia absinthium & Juglans regia leaves extracts on Trichomonas vaginalis, in vitra
Bahman Khalili dehkordi * , Mahmood Rafieian M , Seyed Hoseyn Hejazi , Hoseyn Ali Yusefi , Narges Yektaian , Leyla Shirani-Bidabadi
Parasitology Dept., Shahrekord Univ. of Med. Sci. Shahrekord , bahman@skums.ac.ir
Abstract:   (15012 Views)
Background and aim: Genitourinary infections are of womens hygienic problems in health care systems. Trichomoniasis is one of the most important sexual diseases which are treated with Metronidazole. Due to side effects of the drug and also tendency of people in using herbal medicine, this study aimed to evaluate the effects of three herbs, Achillea millefolium, Artemisia absinthium and Juglans regia leaves extracts, on Trichomonas vaginalis. Methods: In an experimental study, ten tubes were selected and the extracts of these three herbs Achillea millefolium, Artemisia absinthium and Juglans regia leaf extracts with concentrations of 3.12, 6.25, 12.5, 25, 50, 100, 200, 400 and 800 mg/ml were prepared. Then different concentrations of Metronidazole and the three herbs extracts were diluted in 2%DMSO and added to the cell cultures. After 6, 12, 24, 48 and 72 hours, samples were tested for dead or alive and also for their mobility of the parasite. Data were analyzed by ANOVA test. Results: The extracts of these three herbs caused an increase in immobility of the parasites. The rate of immobility had direct relationship with time and immobility was continuously increased after 24, 48 and 72 hours. The results were suggestive that Achillea millefolium, Artemisia absinthium & Juglans regia hydroalcoholic exteracts were significantly more effective in reduction of parasites, in vitro (P<0.05) however, Metronidazole after half an hour caused immobility of parasite versus 24 hour for plant extract. Conclusion: Our study showed that the extracts of the three mentioned herbs had effect on growth of Trichomonas vaginalis however, further studies are needed to show the effects of these herbs in animal models and volunteer infected people.
Keywords: Achillea millefolium, Artemisia absinthium, Juglans regia, Trichomonas vaginalis .
Full-Text [PDF 180 kb]   (2047 Downloads)    
Type of Study: Research | Subject: parasitology
Received: 2011/06/2
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Khalili dehkordi B, Rafieian M M, Hejazi S H, Yusefi H A, Yektaian N, Shirani-Bidabadi L. Effect of Achillea millefolium, Artemisia absinthium & Juglans regia leaves extracts on Trichomonas vaginalis, in vitra. J Shahrekord Univ Med Sci. 2011; 12 (4) :62-69
URL: http://journal.skums.ac.ir/article-1-442-en.html


Volume 12, Issue 4 (suppl1 2011) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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