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:: Volume 20, Issue 2 (6-2018) ::
J Shahrekord Univ Med Sci 2018, 20(2): 100-108 Back to browse issues page
Evaluating the effect of pentazocine and dextromethorphan on progesterone induced depression in female mice
Azadeh Mesripour * , Valiollah Hajhashemi , Farahnaz Shafiei
Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. Iran , a_mesripour@yahoo.com
Abstract:   (369 Views)
Background and aims: Progesterone is a female reproductive hormone. Increasing progesterone levels during menstruation or taking synthetic progesterone in oral contraceptives causes some depression in some women. Sigma receptors are considered as new targets in depression medication. Progesterone other than hormonal effects is a neuro-steroid and is an antagonist to sigma receptors. So, the aim of the current study was to investigate the effect of co-concomitant use of progesterone with sigma agonist drugs, dextromethorphan or pentazocine on depression test.
Methods: This research is a basic- applied study. Experiments were performed on female mice weighing 25-30 g. The forced swimming test was used to investigate depression. Progesterone
10 mg/kg along with dextromethorphan HBr 30 mg/kg, or pentazocine 2.5 mg/kg were administered on the first day and 30 min before the FST on the second day. Data were analyzed using One-way ANOVA and Tukey tests.
Results: Progesterone led to an increase in the immobility time (over 3 minutes) in mice, which is a criterion for animal depression (P<0.05). The immobility of animals was decreased by following consumption of dextromethorphan (100s±13) (P<0.001), and pentazocine (124s±6.9) (P<0.01). These changes were in parallel with antidepression medications by fluvoxamine.
Conclusion: Since depression caused by progesterone is resolved by Sigma agonists, Sigma receptors are responsible for depression caused by high doses of progesterone. So, these agonists can be considered as an effective antidepressant in progesterone medications with high dose.
Keywords: Depression, Sigma receptor, Progesterone, Forced swim test.
Full-Text [PDF 530 kb]   (168 Downloads)    
Type of Study: Research | Subject: pharmacology
Received: 2017/04/4 | Accepted: 2017/06/14 | Published: 2018/06/3
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Mesripour A, Hajhashemi V, Shafiei F. Evaluating the effect of pentazocine and dextromethorphan on progesterone induced depression in female mice. J Shahrekord Univ Med Sci. 2018; 20 (2) :100-108
URL: http://journal.skums.ac.ir/article-1-3309-en.html

Volume 20, Issue 2 (6-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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