:: Volume 20, Issue 2 (6-2018) ::
J Shahrekord Univ Med Sci 2018, 20(2): 1-12 Back to browse issues page
Comparison of sperm PAWP and chromatin status between normozospermic and ab-normozoospermic men
Marziyeh Tavalaee * , Leila Azadi , Mohammad Hossein Nasr- Esfahani
Reproductive Biomedicine Research Center, Reproductive Biotechnology Dept., Royan Institute for Biotechnology, ACECR, Isfahan, I.R. Iran , tavalaee.royan@gmail.com
Abstract:   (1245 Views)

Background and aims: Sperm postacrosomal WW binding protein (PAWP) was expressed during spermiogenesis and recently introduced as one of sperm factors involved in oocyte activation. Therefore, the aim of this study was to compare sperm PAWP and chromatin status between individuals with normal (normozospermia) and abnormal (ab-normozoospermia) sperm parameters.

Results: Significant differences were observed in sperm parameters such as sperm concentration, motility, morphology between men with normozospermia and ab-normozoospermia. Mean percentage of sperm PAWP was significantly lower in ab-normozoospermic men compared to normozospermic men. In addition, mean percentage of spermatozoa with DNA damage and protamine deficiency were significantly higher in ab-normozoospermic men compared to normozospermic men. In addition, significant associations were observed between percentages of sperm PAWP with sperm parameters.

Conclusion:  The results of the current study show that in men with ab-normozoospermia, sperm functional tests such as DNA damage, protamine deficiency, and also percentage of sperm factor (PAWP) related to oocyte activation were in range of abnormality. Therefore, assessment of these tests can be efficient in the decision of treatment in infertile men.

Keywords: PAWP, DNA damage, Protamine deficiency, Sperm parameters, Male infertility
Full-Text [PDF 869 kb]   (377 Downloads)    
Type of Study: Research | Subject: embryology
Received: 2017/01/3 | Accepted: 2017/04/22 | Published: 2018/05/29


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Volume 20, Issue 2 (6-2018) Back to browse issues page