[Home ] [Archive]   [ فارسی ]  
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 20, Issue 2 (6-2018) ::
J Shahrekord Univ Med Sci 2018, 20(2): 1-12 Back to browse issues page
Comparison of sperm PAWP and chromatin status between normozospermic and ab-normozoospermic men
Marziyeh Tavalaee * , Leila Azadi , Mohammad Hossein Nasr- Esfahani
Reproductive Biomedicine Research Center, Reproductive Biotechnology Dept., Royan Institute for Biotechnology, ACECR, Isfahan, I.R. Iran , tavalaee.royan@gmail.com
Abstract:   (431 Views)

Background and aims: Sperm postacrosomal WW binding protein (PAWP) was expressed during spermiogenesis and recently introduced as one of sperm factors involved in oocyte activation. Therefore, the aim of this study was to compare sperm PAWP and chromatin status between individuals with normal (normozospermia) and abnormal (ab-normozoospermia) sperm parameters.

Results: Significant differences were observed in sperm parameters such as sperm concentration, motility, morphology between men with normozospermia and ab-normozoospermia. Mean percentage of sperm PAWP was significantly lower in ab-normozoospermic men compared to normozospermic men. In addition, mean percentage of spermatozoa with DNA damage and protamine deficiency were significantly higher in ab-normozoospermic men compared to normozospermic men. In addition, significant associations were observed between percentages of sperm PAWP with sperm parameters.

Conclusion:  The results of the current study show that in men with ab-normozoospermia, sperm functional tests such as DNA damage, protamine deficiency, and also percentage of sperm factor (PAWP) related to oocyte activation were in range of abnormality. Therefore, assessment of these tests can be efficient in the decision of treatment in infertile men.

Keywords: PAWP, DNA damage, Protamine deficiency, Sperm parameters, Male infertility
Full-Text [PDF 869 kb]   (212 Downloads)    
Type of Study: Research | Subject: embryology
Received: 2017/01/3 | Accepted: 2017/04/22 | Published: 2018/05/29
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tavalaee M, Azadi L, Nasr- Esfahani M H. Comparison of sperm PAWP and chromatin status between normozospermic and ab-normozoospermic men. J Shahrekord Univ Med Sci. 2018; 20 (2) :1-12
URL: http://journal.skums.ac.ir/article-1-3229-en.html


Volume 20, Issue 2 (6-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3764