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:: Volume 19, Number 4 (10-2017) ::
J Shahrekord Univ Med Sci 2017, 19(4): 23-34 Back to browse issues page
A review of silver nanoparticles (Ag-NPs) effects on some fertility indices in small male laboratory mice Mus musculus
Mohammad Saeed Heydarnejad *, Goli Ghasemi, Jahangir Kaboutari Konj
Zoology Dept., University of Shahrekod, Shahrekod, I.R. Iran , m_heydarnejad@yahoo.com
Abstract:   (176 Views)
Background and aims: Silver nanoparticles (Ag-NPs) have attracted phenomenal attention in the current years and caused increased a growing concern for human health and the environment. This, in turn increases the risk related to their potential toxicity. This study was aimed to investigate silver nanoparticles (Ag-NPs) effects on some fertility indices of laboratory small male mice Mus musculus.
Methods: In this experimental study, a group of 36 Balb/c small male mice (average weights; 28.5±3 g) were randomly divided three groups (one control and two treatment groups). The control group received water only. The treated groups of mice (1 and 2) received 20 and 50 ppm concentrations of Ag-NPs with oral exposure. Following respected methods and formulas, sperm motility, DSP and sperm count were determined. The data were analyzed by one-way ANOVA using SPSS.
Results: Sperm motility was reduced down to 37.5% and 19.6% in 50 and 20 ppm-Ag-NPs treated groups of mice, respectively when compared to the control. A significant decrease in the DSP was observed in 50 ppm Ag-NPs-treated mice than to 20 ppm treatment and control ones. In addition, epididymis sperm count was reduced down to 14.76% and 36% in 20 and 50 ppm-Ag-NPs treated groups of mice, respectively when compared to the control.
Conclusion: The use of Ag-NPs can lead to reduction of DSP, epididymis sperm storage and motility percentage in male mice.
Keywords: Ag-NPs, DSP (daily sperm production), Epididymis, Mice.
Full-Text [PDF 1053 kb]   (41 Downloads)    
Type of Study: Research | Subject: biology
Received: 2016/08/20 | Accepted: 2016/09/27 | Published: 2017/10/5
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Heydarnejad M S, Ghasemi G, Kaboutari Konj J. A review of silver nanoparticles (Ag-NPs) effects on some fertility indices in small male laboratory mice Mus musculus. J Shahrekord Univ Med Sci. 2017; 19 (4) :23-34
URL: http://journal.skums.ac.ir/article-1-3049-en.html
Volume 19, Number 4 (10-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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