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:: Volume 19, Issue 1 (Apr,May 2017) ::
J Shahrekord Univ Med Sci 2017, 19(1): 52-61 Back to browse issues page
The effects of acute and chronic estrogen deficiency on glucose and lipid profile in ovariectomized rats.
Pedram Rabiei , Abdul Rasul Namjoo *
Department of Pathology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. , ar.namjo72@gmail.com
Abstract:   (2610 Views)

Background and aims: Ovariectomy is a standard experimental model of menopause in rodent to investigate postmenopausal women . The aim of this study was to evaluate effects acute and chronic estrogen deficiency on lipid profile and glucose serum in ovariectomized (OVX) rats.

Methods: In this experimental study, Twenty-four adult female Wistar rats were divided into three groups of eight rats. The first group: sham-control, Second group: ovariectomized rats (for five weeks), Third group: ovariectomized rats (for fifty five weeks). Blood samples were taken  from the right cardiac ventricle in each group at the end of the study.  Fasting blood glucose and Lipid profile biomarkers such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol were determined using enzymatic procedure. VLDL and Atheroginc index were calculated according to computational procedures.

Results: The results indicated that short time ovariectomy cause increase glucose,  triglyceride, high density lipoprotein, low density lipoprotein ,TG/ HDL ratio and Atherogenic index than the long term ovariectomized rats .

Conclusion: These results suggested that long term estrogen deficiency after ovariectomy, improving lipid profile and blood glucose levels compared to the short time estrogen deficiency during ovariectomized rats.

Keywords: Ovariectomy, Menopause, Blood Glucose, Lipid Profile.
Full-Text [PDF 768 kb]   (698 Downloads)    
Type of Study: Research | Subject: other
Received: 2016/04/18 | Accepted: 2016/08/16 | Published: 2017/04/3
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Rabiei P, Namjoo A R. The effects of acute and chronic estrogen deficiency on glucose and lipid profile in ovariectomized rats.. J Shahrekord Univ Med Sci. 2017; 19 (1) :52-61
URL: http://journal.skums.ac.ir/article-1-2880-en.html


Volume 19, Issue 1 (Apr,May 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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