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:: Volume 10, Issue 4 (suppl1 2009) ::
J Shahrekord Univ Med Sci 2009, 10(4): 67-69 Back to browse issues page
Effect of royal jelly on fibrosarcoma tumor in Balb/c mice
Behnam Zamanzad , Hdaetolah Shirzad * , Najmeh Shahinfard , Maream Shirzad , Rahimeh Kordyazdi
, -mail:shirzadeh@yahoo.com
Abstract:   (14353 Views)
Background and aim: Fibrosarcoma is a tumor with the mesenchymal cell origin that is composed of malignant fibroblastic cell in a collagen background. Specific treatments for cancer such as chemotherapy, radiation and surgery have many complications for patients. Royal Jelly is a substance that appears to be effective on immune system. According to the properties of royal jelly, it seems to be effective on both prevention and growth of fibrosarcoma cell. In this study, we aimed to carry out a research to investigate the effect of royal jelly on the growth of WEHI-164 fibrosarcoma cell in singenic Balb/c mice. Methods: Four groups of 7 Balb/c mice from same sex and age were selected. All Four groups were subcutaneously injected with WEHI-164 tumor cell on the day zero in the chest area of the animal. Each test group (group 1-3) was orally given 300, 200 and 100 mg/kg of royal jelly respectively, but control group was not received royal jelly. In every individual mouse, the tumour size was measured every 2 days from day 5 (days 5, 7, 9, 11, 13, 15 and 17). Data were statistically analyzed using Kruskal-Wallis and Mann Whitney-U tests. Result: Our results showed that the mean size of tumor in case group was significantly smaller than the control group in days 11, 13, 15 and 17 (P<0.05). No metastasis was seen in test and control groups. Conclusion: With emphasize on anti tumor effect of royal jelly, it seems that royal jelly has important role in control and regression of fibrosarcoma cells. Since royal jelly showed a delayed effect in control of fibrosarcoma, we suggest that royal jelly be used at least 10 days before tumor inoculation
Keywords: Balb/c mice, Fibrosarcoma, Royal jelly.
Full-Text [PDF 164 kb]   (1339 Downloads)    
Type of Study: Research |
Received: 2011/06/2 | Accepted: 2013/10/30 | Published: 2013/10/30
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Zamanzad B, Shirzad H, Shahinfard N, Shirzad M, Kordyazdi R. Effect of royal jelly on fibrosarcoma tumor in Balb/c mice. J Shahrekord Univ Med Sci. 2009; 10 (4) :67-69
URL: http://journal.skums.ac.ir/article-1-252-en.html


Volume 10, Issue 4 (suppl1 2009) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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