:: Volume 10, Issue 4 (suppl1 2009) ::
J Shahrekord Univ Med Sci 2009, 10(4): 50-56 Back to browse issues page
Effects of Kelussia odoratissima Mozaffarian (KOM) extract on blood lipid in Balb/c mice
Mahrdad Shahrani , Aliasghar Pilehvarian , Soleman Khayri , Azam Asgahri , Efat Farokhi , Neda Parvin , Mahmood Rafieian *
, E-mail:rafieian@yahoo.com
Abstract:   (20589 Views)
Background and aim: Flavonoids constitute a large group of polyphenolic compounds that are found in fruits, vegetables, chocolate, coffee, tea and wine. Consumption of foods rich in flavonoids is associated with a reduced risk of various heart diseases. This experiment was performed to study the antihyperlipidemic effect of Kelussia odoratissima Mozaffarian (KOM) extract in mice. Methods: 70 Balb/c mice were divided into 5 groups of 14 animals as follows: group1 (normal diet), group2 (normal diet+olive oil), group3 (high cholesterol diet+olive oil), group 4 (high cholesterol diet+olive oil+10% KOM extract) and group5 (high cholesterol diet+olive oil+20% KOM extract). Lipid profiles (triglyceride, total cholesterol, LDL, HDL and VLDL) and FBS were determined after 2 weeks of extract consumption. The data were analyzed with SPSS software (version 15) and Kruskal-Wallis test. Results: Following two weeks administration of KOM extract on mice, we found a significant reduction in blood lipid levels and FBS by using 10% KOM extract (P<0.05). KOM extract (20%) caused a significant reduction in the total cholesterol, LDL and HDL levels and the other factors were not changed (P<0.05). Conclusion: KOM may be beneficial in reduction of lipid profiles.
Keywords: Blood lipid, Kelussia odoratissima Mozaffarian, Mice, Triglyceride
Full-Text [PDF 169 kb]   (2150 Downloads)    
Type of Study: Research |
Received: 2011/06/2

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Volume 10, Issue 4 (suppl1 2009) Back to browse issues page