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:: Volume 17, Issue 3 (Aug, Sep 2015) ::
J Shahrekord Univ Med Sci 2015, 17(3): 40-47 Back to browse issues page
The study of interleukin-23 and interleukin-10 serum levels in patients with rheumatoid arthritis compared to osteoporosis and healthy subjects
Ali Shahraki * , Zahra Zakeri , Mahdieh Hossenian
University of Sistan and Baluchestan , ashahraki@science.usb.ac.ir
Abstract:   (4933 Views)
Background and aims: Cytokines play a crucial role in the processes which induce inflammation, joint destruction and extra-articular signs associated with rheumatoid arthritis. The aim of this study was to examine the role of IL-23 and IL-10 in rheumatoid arthritis in pretreatment and post-treatment compared to healthy control subjects and osteoporosis patients. Methods: In this cross-sectional study, 30 patients diagnosed with RA and 30 healthy controls subjects and 15 patients with osteoporosis matched to age and gender were selected. Blood samples were collected from the patients and the control group to determine IL-23 and IL-10 serum levels. The serum levels of IL-23 and IL-10 were measured by ELISA assay. Results: IL-23 serum levels in RA patients were more than IL-23 serum levels in control group and osteoporosis group and was considered a significant difference (P=0.007). IL-23 serum levels in the patient group three months after treatment decreased significantly compared to RA subjects before treatment (P=0.009). There was no significant difference between IL-10 serum levels in RA patients group before treatment compared to control group and osteoporosis group, but IL-10 serum levels in RA group before treatment and three months after treatment showed a significant difference (P= 0.001). Conclusion: The results showed that IL-23 and IL-10 are highly active in RA and these cytokines might be closely involved to pathogenic mechanisms of the disease.
Keywords: Rheumatoid arthritis, Cytokine, Interleukin-23, Interleukin-10, Osteoporosis
Full-Text [PDF 246 kb]   (1103 Downloads)    
Type of Study: Research | Subject: internal medicie
Received: 2014/05/21 | Accepted: 2014/10/28 | Published: 2015/07/24
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Shahraki A, Zakeri Z, Hossenian M. The study of interleukin-23 and interleukin-10 serum levels in patients with rheumatoid arthritis compared to osteoporosis and healthy subjects. J Shahrekord Univ Med Sci. 2015; 17 (3) :40-47
URL: http://journal.skums.ac.ir/article-1-2016-en.html


Volume 17, Issue 3 (Aug, Sep 2015) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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