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:: Volume 17, Issue 3 (Aug, Sep 2015) ::
J Shahrekord Univ Med Sci 2015, 17(3): 128-143 Back to browse issues page
The role of phospholipase Czeta in male fertility as an oocyte activation factor
Samaneh Aghajanpour , Marzieh Tavalaee * , Leila Azadi , Mohammad Hosein Nasr-Esfahani
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran , Tavalaee.royan@gmail.com
Abstract:   (6475 Views)
Background and aims: In the mammalian, after sperm penetration into the oocyte and pass fertilization process, a set of cascade signals initiate that includes oscillations of calcium concentration in free oocyte cytosolic. The aim of this review article was to evaluate the role of Phospholipase Czeta (PLCz) in human oocyte activation and the role of this protein in sperm samples of fertile and infertile men. Methods: In this review, fifty- one published articles related to protein phospholipase Czeta, during 2002-2013, were assessed via the PubMed. Results: Since the discovery of PLCz in 2002, there has been much progress in researcher understanding of this fundamental sperm protein, both at the scientific and clinical level. Despite high fertilization rate after ICSI, some infertile individuals are faced to failed fertilization. Therefore, it is clear that phospholipase Czeta plays a fundamental role in the activation of human oocytes. Thus, genetic, molecular, or biochemical perturbation in this protein causes oocyte activation deficiency. Conclusion: Phospholipase Czeta can be used either as a novel therapeutic agent which rescue oocyte activation deficiency, or as a prognostic/diagnostic biomarker of oocyte activation ability in target sperm samples.
Keywords: Sperm, Oocyte activation, Phospholipase Czeta, Infertility, Failed fertilization
Full-Text [PDF 452 kb]   (2345 Downloads)    
Type of Study: Review article | Subject: embryology
Received: 2013/08/20 | Accepted: 2014/10/20 | Published: 2015/07/29
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Aghajanpour S, Tavalaee M, Azadi L, Nasr-Esfahani M H. The role of phospholipase Czeta in male fertility as an oocyte activation factor. J Shahrekord Univ Med Sci. 2015; 17 (3) :128-143
URL: http://journal.skums.ac.ir/article-1-1649-en.html


Volume 17, Issue 3 (Aug, Sep 2015) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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