[Home ] [Archive]   [ فارسی ]  
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 16, Issue 3 (Aug, Sep 2014) ::
J Shahrekord Univ Med Sci 2014, 16(3): 43-52 Back to browse issues page
Neuroprotective effects of exercise with hydroalcoholic extraction of Eriobotrya japonica on MANF in the Brainstem of parkinson’s rats
Zia Fallah-mohammadi * , Mohammad Aghasi , Marjan Ahmadi-kordasiabi
Sport Physiology Dept., Pardis Babolsar, Mazandaran University, I.R. Iran , ziafalm@yahoo.com
Abstract:   (11010 Views)
Background and aims: Eriobotrya japonica flower extract (EJFE) has abundant amount of phenolic compounds. This study was aimed to examine protective effects of 12 weeks of voluntary exercise on a running wheel and EJFE on intraventricular 6-hydroxydopamine-induced lesion on MANF in the Brainstem of parkinson’s rats. Methods: In this laboratory experimental study, fifty rats were divided into six groups: basic, control parkinson, training, training-parkinson, extract-parkinson and training-parkinson-extract. Training groups were housed in individual cages with attached running wheels and extracts groups during study period received 200 mg/kg extract intraperitoneally in twelve weeks three times per week. To induce parkinson, injection by 6-hydroxy‌dopamine solution (6-OHDA) (dissolved in saline) was administered into intracerebrovenricular (ICV) by a stereotaxic apparatus. MANF levels in the Brainstem were measured by ELISA. Results: Voluntary wheel running and extract significantly prevent decreasing MANF levels in parkinson rats (P=0.001). MANF levels in training group increase and MANF levels in control parkinson decreased, but in training and extract group didn’t prevent decrease levels MANF in the Brainstem of parkinson’s rats (P=0.169). Conclusion: The results of this research showed that pre-treatment with voluntary exercise and hydroalcoholic extraction of Eriobotrya japonica may be increased protective against 6-OHDA toxicity and have protective role against parkinson disease.
Keywords: Eriobotrya japonica, Exercise, 6-hydroxydopamine, MANF, Parkinson
Full-Text [PDF 272 kb]   (1622 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2013/08/12 | Accepted: 2013/11/19 | Published: 2014/07/14
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fallah-mohammadi Z, Aghasi M, Ahmadi-kordasiabi M. Neuroprotective effects of exercise with hydroalcoholic extraction of Eriobotrya japonica on MANF in the Brainstem of parkinson’s rats. J Shahrekord Univ Med Sci. 2014; 16 (3) :43-52
URL: http://journal.skums.ac.ir/article-1-1645-en.html


Volume 16, Issue 3 (Aug, Sep 2014) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3792