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:: Volume 16, Issue 2 (May, Jun 2014) ::
J Shahrekord Univ Med Sci 2014, 16(2): 80-89 Back to browse issues page
A macro-and microscopic local effect of silver nanoparticles on skin wound healing and some biochemical parameters of blood in mice
Samira Rahnama , Mohammad Saeed Heydarnejad * , Mohsen Mobini-Dehkordi , Mohammad Shadkhast , Parisa Yarmohammadi-Samani , Mehdi Najafi
, m_heydarnejad@yahoo.com
Abstract:   (6552 Views)
Background and aims: Presently, silver and its compounds are being used as an appropriate solution to treat burns, open and chronic wound infections. This study is, therefore aimed to evaluate the effects of silver nanoparticles on wound healing and some biochemical parameters of blood and kidney tissues in mice (Mus musculus). Methods: In this experimental study, 50 female BALB/c mice of (weighting 24.2±3.0 g) about 4 weeks were randomly divided into two groups: Ag-NPs and control. After making a wound in all groups, a volume of 50 microliters from the nanosilver solution (10ppm) was applied to the wound bed in the Ag-NPs group while in the control group no nanosilver solution was used but the wound area was washed by distilled water every day. Samplings were performed on days 2, 7, 14 and 21 of the experiment and the wound's surface area measured on succeeding days. Results: The results of the present study show that the percentage of the wound healed in the treated group was significantly greater than in the control group so that the time required to heal in the former was 14 ± 0.82 days and in the latter 20.75 ± 1.03 (P<0.05). There were significant changes in potassium and blood urea nitrogen (BUN) among all groups studies (P<0.05). Conclusion: This study suggests that recovery with a 10 ppm solution of silver nanoparticles, while accelerates the process of wound healing, will notoriously influence on some biochemical parameters of blood. So, although solution of silver nanoparticles is beneficial for healing, it should be cautious in consuming it.
Keywords: Silver nanoparticle, Wound healing, Biochemical parameters, Potassium, Blood urea nitrogen.
Full-Text [PDF 230 kb]   (2148 Downloads)    
Type of Study: Research | Subject: biology
Received: 2013/07/4 | Accepted: 2013/11/6 | Published: 2014/05/31
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Rahnama S, Heydarnejad M S, Mobini-Dehkordi M, Shadkhast M, Yarmohammadi-Samani P, Najafi M. A macro-and microscopic local effect of silver nanoparticles on skin wound healing and some biochemical parameters of blood in mice. J Shahrekord Univ Med Sci. 2014; 16 (2) :80-89
URL: http://journal.skums.ac.ir/article-1-1598-en.html


Volume 16, Issue 2 (May, Jun 2014) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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