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:: Volume 16, Issue 2 (May, Jun 2014) ::
J Shahrekord Univ Med Sci 2014, 16(2): 10-21 Back to browse issues page
The effect of endurance training on the level of tissue IL-6 and VEGF in mice with breast cancer
Sadegh Amani-Shalamzari , Hamid Aghaalinejad * , Shaban Alizadeh , AbdolReza Kazmi , Mohammad amin Saei , Neda Minayi , Fatemeh Shokrolahi
Tarbiat Modares University , aghaalinejad@gmail.com
Abstract:   (6483 Views)
Background and aims: The sport exercises include a potential to prevent breast cancer. The aim of this study was assessing the prophylactic effect and adjuvant therapy of exercise on cytokines involved in angiogenesis in estrogen-dependent breast cancer. Methods: Thirty- two female Balb/C mice were randomly assigned in 4 groups. After orientation in the environment, two groups of mice performed continuous endurance exercise for 8 weeks, and then estrogen-dependent MC4L2 cancer cells were injected to them. After that, one group of each of trained and non-trained mice performed endurance exercise 5 days per week for 6 weeks. Tumor volume was measured by a digital caliper weekly. Finally, the mice were sacrificed tumor tissue was removed. Tumor sample was homogenized and the level of IL-6 and VEGF were measured using ELISA. Results: There was a significant difference in the level of IL-6 and VEGF among the groups and tumor growth (p<0.001). The level mean of IL-6 and VEGF cytokines and tumor growth in groups performing endurance exercise after malignancy (RTE and ETE) was lower than groups not performing (ETR and RTR),(P<0.05). Conclusion: Due to reduction of the level of these cytokines in groups doing exercise before and after malignancy, exercise training is presumed to have adjuvant therapy in estrogen-receptor dependent tumors in addition to very effective prophylactic role.
Keywords: Estrogen receptor dependent cancer, Endurance training, IL-6, VEGF
Full-Text [PDF 259 kb]   (2025 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2013/06/26 | Accepted: 2013/09/29 | Published: 2014/05/20
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Amani-Shalamzari S, Aghaalinejad H, Alizadeh S, Kazmi A, Saei M A, Minayi N et al . The effect of endurance training on the level of tissue IL-6 and VEGF in mice with breast cancer. J Shahrekord Univ Med Sci. 2014; 16 (2) :10-21
URL: http://journal.skums.ac.ir/article-1-1586-en.html


Volume 16, Issue 2 (May, Jun 2014) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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