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:: Volume 14, Issue 6 (Feb,march 2013) ::
J Shahrekord Univ Med Sci 2013, 14(6): 72-81 Back to browse issues page
Preventive effects of hydro-alcoholic extract of Prangos ferulacea (L.) Lindl. on kidney damages of diabetic rats induced by alloxan
Farokh Farokhi , Nagmeh Kafash-farkhad * , Majid Asadi-Samani
1Biology Dept, Urmia University, Urmia, I.R. Iran , E-mail:kafash_embriology@yahoo.com
Abstract:   (8596 Views)
Background and aims: Diabetic nephropathy is one of the most important implication factors in kidney´s physiological function in diabetes mellitus. Having major role in filtration, in hyperglycemic condition kidney has shown more damages in comparison with other tissues. The aim of this study was to investigate kidneys histopathological changes during diabetes and nephropatic diabetic conditions. The effect of Prangos ferulacea on these changes was also evaluted Methods: In this experimental study (40) female Wistar rats with body weight of 200± 20 gr were randomly divided into 5 groups with 8 rats in each group. Diabetes was induced in rats by intrapritoneally injection of alloxan monohydrate in a dose of 120 mg/kg body weight (BW). Root and leaves with stems hydroalcoholic extract of Prangos ferulacea in a dose of 100 mg/kg B.W were injected orally in diabetic rats daily for 4 weeks. At the end of the treatment, renal tissue samples were processed and histological changes were investigated. Result: Diabetic rats compared with control group showed a significant increase in blood glucose and WBC, and a decrease in body weight. Further, renal tissue complications such as: messential matrix expantion, glumerular basement membrane thickness, glumerular shrinkage and increase in lymphocytic infiltration were observed. In diabetic rats treated by roots of hydroalcoholic extract of Prangos ferulacea (L.) Lindl. all of the previous signes were decreased, significantly (P<0.05). Conclution: These results showes that root hydroalcoholic extract of prangos ferulacea had useful effects on renal histopathological distruption induced by diabetes.
Keywords: Diabetic nephropathy, Prangos ferulacea (L.) Lindl., Glumerul
Full-Text [PDF 418 kb]   (1862 Downloads)    
Type of Study: Research | Subject: internal medicie
Received: 2013/01/10 | Accepted: 2013/03/31 | Published: 2013/03/31
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Farokhi F, Kafash-farkhad N, Asadi-Samani M. Preventive effects of hydro-alcoholic extract of Prangos ferulacea (L.) Lindl. on kidney damages of diabetic rats induced by alloxan. J Shahrekord Univ Med Sci. 2013; 14 (6) :72-81
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Volume 14, Issue 6 (Feb,march 2013) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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