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:: Volume 6, Issue 3 (autuman 2004) ::
J Shahrekord Univ Med Sci 2004, 6(3): 39-45 Back to browse issues page
Effects of electrical stimulation of ventral tegmental area on morphine addiction in rat
Ali Nasimi , Abolghasem Karimian , Hojatolah Alaei
Abstract:   (6800 Views)
Background and aim: Ventral tegmental area (VTA) is located in the mesencephalon and it is one of the main nuclei that play a major role in drug abuse or addiction. In this study we investigated the effect of electrical stimulation of the VTA on addiction to morphine. Methods: Intravenous self-administration was used to quantify the level of drug-dependence. Twenty-four Wistar rats were divided into three groups: 1) Sham or saline group that had surgery and received saline by self-administration. 2) Control or morphine group that had surgery and received morphine by self-administration. 3) Case or morphine + stimulation (25 μA 100 Hz 0.14 ms period for 10 minutes) group that had surgery and received electrical stimulation 15 minutes before morphine self-administration. Results: Addiction was seen only in the morphine group, and electrical stimulation of the VTA prevented the addiction. Conclusion: Electrical current stimulates all type of the neurons in the VTA. Since dopaminergic neurons comprise two-third of its neurons, VTA stimulation may cause the release of dopamine in the nucleus accumbence and produce rewards so that the animal needs no further rewards from morphine.
Keywords: Key words: Addiction, Morphine, VTA.
Full-Text [PDF 260 kb]   (2280 Downloads)    
Type of Study: Research |
Received: 2011/06/2
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nasimi A, karimian A, Alaei H. Effects of electrical stimulation of ventral tegmental area on morphine addiction in rat. J Shahrekord Univ Med Sci. 2004; 6 (3) :39-45
URL: http://journal.skums.ac.ir/article-1-119-en.html


Volume 6, Issue 3 (autuman 2004) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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