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:: Volume 14, Issue 2 (May,Jun 2012) ::
J Shahrekord Univ Med Sci 2012, 14(2): 47-54 Back to browse issues page
Serum levels of triiodothyronine, thyroxin and thyrotropin in the patients with major depressive, in comparison with normal patients
Seyedmehrdad Kassaee * , Mehran Kassaee , Asghar Seif
Biology Dept., Hamedan Branch, Islamic Azad University, Hamedan, I.R. Iran , E-mail:seyedmehrdadkassaee@yahoo.com
Abstract:   (8898 Views)
Background and aims: Depression is the most common psychiatric disorder and its relation with some hormone has been the focus of attention in the recent studies. In this study, the serum levels of Triiodothyronine (T3), thyroxin (T4) and thyroid-stimulating hormone (TSH) of the patients with major depressive have been compared with the healthy control adults. Methods: In this case –control study, 32 patients who were diagnosed to be depressed through (beck depression test) referred to Hamedan hospital and 32 healthy participants homogenized of gender and age to depression group were chosen. The level of triiodothyronine, thyroxin and thyroid stimulatiy hormone were measured in 2 groups. Data were analyzed using X2, independent t-test, ANOVA and regression logistic tests. Results: The mean serum levels of T4 and TSH were significantly higher in depressed patients than control group (P=0.01), whereas there was no significant difference in the mean serum level of T3 between two groups (P>0.05). Comparing the clinically depressed group (the mark higher than 21 in beck test) to non-clinically depressed group (the mark bellow 21 in Beck test) TSH level significantly increased (P=0.001). According to logistic regression, one unit increase in serum levels of T4 and TSH will increase the probability of the occurrence of depression by 1.3 and 1.7 times, and clinical depression by 1.2 and 2.09 times respectively. Conclusion: The mean levels of serum T4 and TSH in major depression are higher than the control group. The measurement of two hormones might be useful in prediction of the occurrence of depression.
Keywords: Logistic Models, Major Depressive Disorder, Triiodothyronine, Thyroxin, Thyroid Stimulating Hormone
Full-Text [PDF 194 kb]   (1302 Downloads)    
Type of Study: Research | Subject: general
Received: 2012/06/2 | Accepted: 2017/09/2 | Published: 2017/09/2
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Kassaee S, Kassaee M, Seif A. Serum levels of triiodothyronine, thyroxin and thyrotropin in the patients with major depressive, in comparison with normal patients. J Shahrekord Univ Med Sci. 2012; 14 (2) :47-54
URL: http://journal.skums.ac.ir/article-1-1113-en.html


Volume 14, Issue 2 (May,Jun 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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