Background and aims: Systemic Lupus Erythematosus (SLE) is an inflammatory multi systemic autoimmune disease with auto antibodies. The aim of this study was to consider the effect of Mindfulness Based Cognitive Therapy (MBCT) on quality of life in patients with SLE.

Methods: In this experimental study with randomized clinical trial design which was conducted on 46 SLE patients referring Imam Ali Clinic in Shahrekord, southwest Iran within one year, the patients (totally 46 patients in 2 groups of 23 each) were assigned into one of the treatment and control groups alternately. Both groups underwent routine medical care. The treatment group underwent eight group sessions of MBCT, as well. The patients were assessed by Quality of Life Test (SF-36) prior to, after, and six months after intervention. The data were analyzed using analysis of covariance.

Results: The mean scores of mental quality of life in trial group were significantly more than control group at post-intervention and follow-up stage (P=0.001, P=0.004). The mean scores of somatic quality of life in trial group were significantly more than control group at post-intervention but weren’t significantly at follow-up intervention (P=0.001 vs P=0.157).

Conclusion: The results demonstrated that MBCT has persistent and continuum effect on access scores of mental quality of life in patients with SLE.