Background and aims: Exhaustive exercise leads to muscle damage and reduces energy sources such as glucose. The purpose of the present study was to investigate the effect of troxerutin supplementation on serum glucose level and lactate dehydrogenase activity after exhaustive swimming in male rats.

Methods: In this experimental study, 32 male Wistar rats were randomly divided into 4 groups including control, exercise + 75 mg/kg, exercise + 150 mg/kg and exercise + 300 mg/kg troxerutin treatment. All animals performed swimming training for 30 days, 5 d/wk. Troxerutin was administered by oral gavage once daily for four weeks. On the 30 th day, the rats performed an exhaustive swimming exercise, and serum glucose level and lactate dehydrogenase activity were measured.

Results: The results showed that troxerutin supplementation significantly increased serum glucose level compared to the control group (P<0.001) and as well as lactate dehydrogenase activity significantly reduced in exercise + troxerutin (300 mg/kg) compared to the control and exercise + troxerutin (150 mg/kg) (P<0.05).

Conclusion: The present study showed that troxerutin can significantly affect in reducing of muscle damage exhaustive swimming exercise-induced.