Background and aims: Diabetes is chronic disease which induces increase in lipid profile. The aim of the present study was to review the effect of moderate intensity endurance training and lipid lowering genistein in diabetic rats.

Methods: 48 diabetic rats selected and divided in 6 groups of 8 rats: 1) first week control 2) last week control, 3) moderate intensity endurance training 4) genistein consumption 5) moderate intensity endurance training with genistein and 6) sham. For investigating the effects of diabetes induction, 16 health rats divided in 2 groups of first week control and last week control. During
8 weeks rats of groups 3 and 5 ran on treadmill 3 sessions per week and 60 minutes per week with speed of 10-17 meter per minute and groups 4 and 5 consumed 30 mg/kg genistein daily. For statistical analysis of data used one way ANOVA and Tukey post hoc tests (P≤0.05).

Results: Induction of diabetes decrease HDL and increase TG, Cho, LDL and VLDL of rats significantly (P≤0.05), endurance training, genistein consumption and endurance training with genistein have significant effect on increase of HDL and decrease of TG, Cho, LDL and VLDL of diabetic rats (P≤0.05). Also endurance training with genistein rather than genistein consumption has more effect on reduction of LDL and increase of HDL (P≤0.05).

Conclusion: Moderate intensity endurance training and lipid lowering genistein have interactional effects in streptozotocin induced diabetic rats.