[Home ] [Archive]   [ فارسی ]  
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 19, Issue 6 (2-2018) ::
J Shahrekord Univ Med Sci 2018, 19(6): 99-113 Back to browse issues page
Role of long non-coding RNAs in hematopoiesis and hematological malignancies
Mona Agha Mohammad Hossein Tajrishi , Amir Atashi * , Elham Sajjadi , Zeinab Saei
Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, I.R. Iran , atashia@gmail.com
Abstract:   (1378 Views)
Background and aims: Several studies have classified a group of non-coding RNA’s, known as long non coding RNA’s (lncRNA), which are responsible for cell differentiation and causing diseases. It is claimed that lncRNAs play a significant role in hematopoiesis regulation, including differentiation of myeloid, lymphoid and erythroid lineages. The aim of this article is to review different kinds of lncRNAs which are involved in hematopoiesis, further on; the article describes the dysregulation of lncRNAs in hematologic disorders.
Methods: In this study, different articles were recruited from different valid databases such as, ISI, PubMed and Scopus.
Results: lncRNAs have recently been identified in a wide genomic scale and only some of their roles have been recognized. lncRNAs have various biological roles in gene expression, cell differentiation and pathogenesis. Recent studies have indicated the expression of lncRNAs in many types of cancers such as blood malignancies.
Conclusion: The abnormal expression of lncRNAs can lead to anomalies in differentiation of blood cells which may lead to malignancies. Studies show that lncRNAs can be served as an indication for diagnosis and prognosis of many diseases as well as being used as a replacement for treatment.
Keywords: Long noncoding RNAs, Hematopoiesis, Hematopoietic disorders.
Full-Text [PDF 1179 kb]   (477 Downloads)    
Type of Study: Review article | Subject: hematology
Received: 2016/04/24 | Accepted: 2016/12/14 | Published: 2018/02/9
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Agha Mohammad Hossein Tajrishi M, Atashi A, Sajjadi E, Saei Z. Role of long non-coding RNAs in hematopoiesis and hematological malignancies. J Shahrekord Univ Med Sci. 2018; 19 (6) :99-113
URL: http://journal.skums.ac.ir/article-1-2887-en.html

Volume 19, Issue 6 (2-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 3781