Background and aims: Colorectal cancer (CRC) is the third most common cancer worldwide and is caused by the interaction of genetic and environmental factors. Angiogenesis is the formation of new blood vessels in the body that plays a critical role in tumor growth and metastasis. In this study, it was aimed to examine 2 Gene Polymorphism of the Vascular Endothelial Growth Factor (VEGF) and susceptibility to colorectal cancer in Iranian patients.

Methods: In this case-control study, 280 patients with colon adenocarcinoma selected of the pathology centers in Tehran (Sina and Taleghani) hospital as cases and 372 healthy subjects as controls were selected from the same centers. Control subjects were matched according to sex and age. Patients with positive family history of cancer were excluded. Data collected included age, sex, tumor location, stage of disease and cancer tissue. In this study, it was used Real time PCR techniques to genotype rs833061 and rs2010963 polymorphisms.

Results: Colorectal cancer in men was more than women (62.7%). Age of most people was under 60 years. Most tumors were located in the colon (69. From the point of tumor tissue differentiation, most of them were placed in the moderate level (54.8%) and pathology stage most of them were in stage III (72.5%). In the current study, between the two groups in terms of susceptibility to colorectal cancer, it was a significant relationship based on onset age T/C genotype of rs833061 polymorphism with age<60 (P=0.008).

Conclusion: The results of this study show that people who have been named genotype are more sensitive than others to the risk of colorectal cancer, and also due to the increasing prevalence of colorectal cancer diseases in the worldwide and possibility of prevention, it can be used this genotype as molecular markers for early detection of the disease.