Background and aims: In recent years, the role of vitamin D deficiency in the incidence and aggravation of types of allergy have been considered and much study has been done in this regard. Because vitamin D deficiency and as well as the prevalence of allergy is the important issues in the health field, this study was aimed to investigate the relationship between vitamin D level and and IgE in children in Tehran.

Methods: In a cross sectional study, 112 allergic children aged less than 12 years (64 boys and 48 girls) were evaluated. Vitamin D was classified in three levels as deficient (<20 ng/mL), insufficient (≥20 and <30 ng/mL), and  sufficient (≥30 ng/mL). Vitamin D and total IgE levels were measured by ELISA. Prick skin test was used to confirm the presence of specific IgE. Finally, the data were analyzed by SPSS version 20.

Results: The mean of vitamin D level was 64.17±27.14ng/ml that fall into insufficient range. The abnormal level of vitamin D was present in 61.9% (20.5% insufficient and 41.4% deficient). Vitamin D deficiency was significantly higher in girls(P=0.03). Although vitamin D deficiency was increased with age, the mean of vitamin D deficiency was not different between age groups. However, 43.8% of total IgE levels were higher than normal range, there was no association between serum vitamin D and IgE level.

Conclusion: Given the prevalence of vitamin D deficiency in the children and its impact on the incidence of allergic diseases, design a national project to determinate the vitamin D deficiency levels and its associated risk factors, and screening of vitamin D deficiency seems necessary.