Background and aims: Staphylococcus aureus is one of the most common causes of nosocomial infections. The aim of the current study was to examine the prevalence of nasal carriers of Staphylococcus aureus and its relationship with the pollution there.

Methods: In this short research paper in the first stage, a random sample of employees from different wards of Kashani and Hajar were taken, and after culture, the results were analyzed using SPSS software and statistical tests of Chi-square and Fisher's exact.

Results: Of 90 patients who were selected in the first stage, 44 patients (48.8%) in both innings, the samples were contaminated. Statistically significant relationship between the numbers of nasal carriers of the infection was observed (P<0.05).

Conclusion: This study showed that nasal carriers of Staphylococcus aureus can cause contamination hands to this bacteria and this help the prevalence of bacteria especially in hospitals.