Background and aims: Allergy to food substances is considered as one of global health problems particularly in developing countries and its rate, as with other allergic disorders, is growing. The aim of this study was to study frequency of common food allergens in the region.

Methods: In this descriptive-analytical study conducted on 230 children 1 to 6 years referring Imam Ali Clinic, Shahrekord in 2014 enrolled by convenience sampling. The children were assigned to two groups of 115 each, those with suspected food allergy and those without food allergy symptoms, and the common food allergens consisting of cow milk, egg, and groundnut were investigated for skin test. T-test and chi-square statistics were used for data analysis.

Results: There was a statistically significant difference between allergic to peanuts, eggs and other allergens (Pepper, banana, fish, kiwi, melons, wheat, peaches, eggplant, squash, tomato and watermelon) in studied groups (P<0.001). 79(68.7%) of children in case group and 22(19.1%) in the control group showed allergic reaction to at least one food. The most allergies 79 children (34.3%) were related to other allergens and the least was 2 children (0.9%) related to allergy to milk. 64(55.7%) in the case group had the highest allergy to other allergens, then 43 individuals (37.4%) had allergy to eggs  and 32(27.8%) individuals had allergy to peanuts.

Conclusion: Other allergens were identified with the highest and cow’s milk with the lowest frequency of food allergy in the children. This allergy was higher in food allergy-suspected children compared to the control group.