Background and aims: Urinary tract infection is a common cause of outpatient visits of patients in medical centers and sometimes they need to be admitted because of their deterioration of an underlying condition or incapacitating. The aim of this study was the comparison of cranberry pills and nitrofurantoin pill to prevent recurrent urinary tract infection among 15-45 years old women who goes to the Kashani hospital’s clinic in Shahrekord.

Methods: This study was a clinical trial on 3 groups each one contains twenty one 15-45 years old women with recurrent urinary tract infection that are visited in Kashani hospital’s clinic. Patients were randomly divided into 3 groups. The first group received cranberry 500 mg tablets for 6 months and the second group received nitrofurantoin 100 mg during night for 6 months and the third group received placebo. These patients were followed up during the 6 months and once in two months the patient were examined clinically, Urinary Analysis, Urinary Culture, and in terms of recurrent cystitis.

Results: In our study, no significant difference was observed between the groups in terms of recurrent UTI recurrence, although there were differences (P>0.005). Positive urine culture in nitrofurantoin group was 9.6% and in cranberry group was 19% and in placebo group was 33.4% during 6 months. In terms of dysuria in 6 months and the second time there was significant difference between placebo and cranberry (P=0.004). Dysuria in cranberry group was 14.2% and in placebo group was 56.2% during 6 months.

Conclusion: According to the results, taking the cranberry pills with the dose of 500 mg per day can reduce dysuria in patients with recurrent urinary tract infection.