Background and aims: Paraoxonase-1, Adiponectin and Hydrogen Peroxide are among indexes that are influenced by sedentary lifestyle; and it is possible that they’ll be effective on blood pressure. However, it is not clear the relationship between their changes with blood pressure as a result of participation in regular physical activity. So, the aim of this research was to investigate the effect of 12 weeks moderate aerobic exercise on relationship between Paraoxonase-1, Hydrogen Peroxide and Adiponectin changes with systolic and diastolic blood pressure of Men’s with high blood pressure.

Methods: This research was a semi-experimental with repeated measurement method, and 10 men (age range= 37.9±2.68) with high blood pressure (systolic pressure: 140.531±0.23 and diastolic 90.71±0.05) after completing the consent form participated in this research. The subjects participated in a 12-week aerobic moderate exercise (55-70 percent of Maximum Heart Rate). Physiological markers and serum levels of Adiponectin, Paraoxonase-1 (PON-1) and Hydrogen Peroxide (H₂O₂) were assessed in baseline stage, fourth weeks, eighth weeks and twelfth weeks. The Liner Mixed Model was used to evaluate the association between markers.

Results: Statistical analyses showed no significant relation between Adiponectin and PON-1 with systolic blood pressure (SBP) and diastolic blood pressure (DBP) (Respectively: P=0.150, P=0651 and P=0.165, P=0.520). However, the relationship between H2O2 with SBP and DBP (Respectively: P=0.020 and P=0.048) reported significantly.

Conclusion: it Seems that 12 weeks of aerobic moderate exercise leads to a reduction of blood pressure in Men’s with high blood pressure by reducing of ROS and oxidative stress.