در حال انتقال سرور
   [Home ] [Archive]   [ فارسی ]  
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 20, Issue 1 (4-2018) ::
J Shahrekord Univ Med Sci 2018, 20(1): 45-53 Back to browse issues page
Association study of rs7192 polymorphism of HLA-DRA gene with male infertility occurrence in Isfahan province of Iran
Majid Motovali-Bashi * , Salehe Akbari , Seyed-morteza Javadirad
Biology Dept., University of Isfahan, Isfahan, I.R. Iran , mbashi@sci.ui.ac.ir
Abstract:   (854 Views)
Background and aims: One third of male factors related to infertilities are basically unknown and it has been predicted to be most of the unknown infertilities based on genetic abnormalities. On the other hands, the effect of HLA-DRA genes on spermatogenesis has been shown recently. So, this study was aimed to assess the association of rs7192 polymorphic site of HLA-DRA gene on male infertility in Isfahan province of Iran.
Methods: 100 infertile men with azoospermia or severe oligozoospermia as case group and equal numbers of fertile men as control individuals were selected. Genomic DNA of peripheral blood was extracted after the written consent was taken. rs7192 polymorphic site has been analyzed by ARMS-PCR method in the case and control groups.
Results: According to the results, the frequency of G allele was higher in infertile men than the T allele; but, allele frequency differences was not significant between the case and control groups (OR=0.86, P=0.47). However, it has been shown that GG homozygous in comparison to TT homozygous show an increased risk of male infertility but it was not statistically significant (OR=1.47, P=0.4). In parallel, comparison of GG + GT genotypes to TT ones was not also statistically significant between infertile and fertile men (OR=1.43, P=0.4).
Conclusion: Association study of polymorphic rs7192 did not show any significant relationship among men infertile with azoospermia or severe oligozoospermia in Isfahan province of Iran.
Keywords: Male infertility, HLA-DRA gene, rs7192 polymorphism
Full-Text [PDF 1049 kb]   (232 Downloads)    
Type of Study: Research | Subject: genetic
Received: 2016/12/28 | Accepted: 2017/02/13 | Published: 2018/04/3
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Motovali-Bashi M, Akbari S, Javadirad S. Association study of rs7192 polymorphism of HLA-DRA gene with male infertility occurrence in Isfahan province of Iran. J Shahrekord Univ Med Sci. 2018; 20 (1) :45-53
URL: http://journal.skums.ac.ir/article-1-3218-en.html


Volume 20, Issue 1 (4-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3792