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:: Volume 20, Issue 1 (4-2018) ::
J Shahrekord Univ Med Sci 2018, 20(1): 7-14 Back to browse issues page
Determine the relationship between resistin levels and Metabolic Syndrome components
Fariba Sakhaei , Leila Salehizadeh , Ziaaldin Samsam Shariat * , Mahtab Keshvari , Sedigheh Asgary
Clinical Biochemical Dept., Isfahan University of Medical Sciences, Isfahan, I.R. Iran , samsam@pharm.mui.ac.ir
Abstract:   (862 Views)
Background and aims: Metabolic Syndrome is a collection of risk factors which increase the risk of cardiovascular disease and type II Diabetes. The aim of this study was to determine the relationship between resistin levels and Metabolic Syndrome components.
Methods: This case control study was conducted on a subgroup of patients referred to the clinic of Isfahan Cardiovascular Research Center. Serum sample from 76 person (38 healthy individuals and 38 patients with metabolic syndrome) were analyzed by Eliza for resistin enzyme-linked immunosorbent assay. Association between serum resistin and levels of triglycerides(TG), total cholesterol (TC), LDL-C, HDL-C, fasting blood sugar (FBS), waist circumference, body mass index and systolic and diastolic blood pressure was determined.
Results: Serum levels of total cholesterol, triglycerides, fasting blood sugar and LDL cholesterol was significantly(P<0.001) higher in the MetS compared with control group and serum levels of HDL cholesterol was significantly lower in patients with MetS than healthy controls (P<0.001). Serum resistin levels were significantly higher in the MetS compared to the control group (1.70±0.54, P=0.004). Serum levels of resistin were found to be significantly correlated with levels of weight (r=0.396, P=0.014) and BMI (r=0.302, P=0.050) and TG (r=0.384, P= 0.023). No significant correlation between resistin and MetS components was observed in the healthy people (P>0.05).
Conclusion: Serum resistin levels are higher in people with metabolic syndrome than in healthy individuals end can be considered for the early detection and severity of this syndrome in the future.
Keywords: Metabolic syndrome, Resistin, Cardiovascular disease
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Type of Study: Research | Subject: biochimistery
Received: 2016/12/19 | Accepted: 2017/02/18 | Published: 2018/04/3
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Sakhaei F, Salehizadeh L, Samsam Shariat Z, Keshvari M, Asgary S. Determine the relationship between resistin levels and Metabolic Syndrome components. J Shahrekord Univ Med Sci. 2018; 20 (1) :7-14
URL: http://journal.skums.ac.ir/article-1-3208-en.html

Volume 20, Issue 1 (4-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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