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:: Volume 19, Issue 6 (2-2018) ::
J Shahrekord Univ Med Sci 2018, 19(6): 91-98 Back to browse issues page
The comparison of the expression of miR-126 in breast and normal tissue and the association between these data and age of Iranian population
Maedeh Rouigari , Kamran Ghaedi , Parisa Mohammadynejad
Biology Dept., University of Isfahan, Isfahan, I.R. Iran
Abstract:   (917 Views)

Background and aims: Breast cancer is the most common cancer among women. miRNAs are a class of non-coding RNAs which play an important role in control of gene expression at
post-transcriptional level. miR-126, an intronic miRNA derived from EGFL7 gene. miR-126 has been revealed to down-regulate and play a tumor suppressive role in breast tumors. The aim of this study was to assess the expression of miR-126 in breast and normal tissue and an association between these data and age of Iranian population.
Methods: In this study, expression of miR-126 was assessed in cancer specimen and normal breast tissues by Real Time RT-PCR. Then, the association between expression of miR-126 and age were calculated. U6 gene was selected as the control. Data were analyzed statstically by ANOVA and t- test.
Results: Data indicated that the expression of miR-126 was significantly down-regulated in tumor status. Also, the expression of miR-126 had a significantly difference between normal and malignant and benign tumor. (P<0.05). In addition, there was a relationship between age and the expression of miR-126, and the age of the patients who had a low expression of miR-126 was less than the age of  the patients that had the high expression of miR-126.
Conclusion: The results shows that miR-126 expression decreases in tumor status. In addition, a significant correlation between expression of miR-126 and age of patients was observed

Keywords: Breast cancer, Gene expression, miR-126, Real Time RT-PCR
Full-Text [PDF 890 kb]   (136 Downloads)    
Type of Study: Research | Subject: genetic
Received: 2016/10/16 | Accepted: 2016/12/24 | Published: 2018/02/9
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Rouigari M, Ghaedi K, Mohammadynejad P. The comparison of the expression of miR-126 in breast and normal tissue and the association between these data and age of Iranian population. J Shahrekord Univ Med Sci. 2018; 19 (6) :91-98
URL: http://journal.skums.ac.ir/article-1-3130-en.html


Volume 19, Issue 6 (2-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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