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:: Volume 19, Issue 6 (2-2018) ::
J Shahrekord Univ Med Sci 2018, 19(6): 83-90 Back to browse issues page
The study of lowering effects of blood presure in statins in Iran (Atorvastatin, Rosuvastatin, simvastatin) on mild hypertension
Sahar Yadollahi farsani * , Farshad Roghani
Cardiology Dept., Isfahan University of Medical Sciences, Isfahan, I.R. Iran , saharyadollahi@gmail.com
Abstract:   (1538 Views)
Background and aims: Hypertension is the most important risk factor and a serious threat for cardiovascular diseases. This study was aimed to determine the effect of the statins drugs (included Atrovastatin, simvastatin and Rosuvastatin) in Iranian's population on mild hypertention.
Methods: In a clinical trial, 120 patients with mild hypertension were selected and randomly distributed in four groups of 30 patients. The first group to third received Atrovastatin 20 mg daily and simvastatin 20 mg daily and Rosuvastatin 10 mg daily for one month and as a control group, the fourth group did not receive any statin. Four groups of patients before and 1 month after treatment were examined and their blood pressure was measured manually by sphygmomanometer in Iranian's population with mild hypertention. Finally, data were entered into SPSS software and analyzed using Chi-Square, one-way ANOVA, and paired t-test.
Results: Diastolic blood pressure decreased about 15.68±3.4% in the group receiving Atrovastatin, 7±2.7% in the simvastatin group, 6.4±0.3% in the group receiving Rosuvastatin, and 6.5±3.4% in the placebo group, respectively, while the percentage reduction in systolic blood pressure were different between the four groups (P= 0.01), and the group receiving Atrovastatin showed decreaseing the highest systolic and diastolic blood pressure.
Conclusion: Based on these findings, it can be concluded that the regular uses of statins may be had lowering effect on blood pressure in patients with mild hypertension.
Keywords: Mild hypertension, Hyper lipidemia, Statins, Atrovastatin, Rosuvastatin, Simvastatin.
Full-Text [PDF 808 kb]   (207 Downloads)    
Type of Study: Research | Subject: Cardiology
Received: 2016/10/10 | Accepted: 2016/12/5 | Published: 2018/02/2
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Yadollahi farsani S, Roghani F. The study of lowering effects of blood presure in statins in Iran (Atorvastatin, Rosuvastatin, simvastatin) on mild hypertension. J Shahrekord Univ Med Sci. 2018; 19 (6) :83-90
URL: http://journal.skums.ac.ir/article-1-3126-en.html

Volume 19, Issue 6 (2-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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