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:: Volume 20, Issue 1 (4-2018) ::
J Shahrekord Univ Med Sci 2018, 20(1): 70-78 Back to browse issues page
The relation of TSH and depression in hypothyroid patients
Afsaneh Talaei , Nasrin Rafiei Dr, Fatemeh Rafiei , Ali Chehrei
Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, I.R. Iran. , afsanehtalaeii@yahoo.com
Abstract:   (603 Views)
Background and aims: Many of hypothyroid patients that are under treatment with levothyroxine. In spite of normal blood level of thyroid hormones, are suffering from depression symptoms that show it is necessary the normal level of TSH should be detected specificially related to depression.
Methods: A cross-sectional study was conducted on 174 hypothyroid patients under treatment with levothyroxine who referred to endocrinology clinic with TSH levels of 0.5-5 MIU/L for more than one year. Laboratory tests including TSH, T4 and T3 were performed. Beck depression questionnaire was completed for all patients by trained experts. Based on Beck depression test, scoreless and more than 10 was considered healthy and depressed, respectively. Then, TSH cut-off values based on depression was determined by Roc Curve analysis.
Results: 174 hypothyroid patients (Female: 116, Male: 58) with mean age 45.5±11.7 years old were entered to the study. According to Roc Curve analysis, the optimal cut-off value of TSH based on depression was estimated 2.5 MIU/L with 89.66% sensitivity.
Conclusion: The present study suggested that a TSH cut-off value for treatment of depression in hypothyroid patients should be based on depression, not just based on population studies. Based on the assessment of depression, our study concludes that a TSH cut-off value of 2.5 MIU/L is optimal. This cut point can provide the greatest effect in terms of depression improvement and quality of life for these patients.
Keywords: TSH, Cut-off, Hypothyroid, Depression.
Full-Text [PDF 1055 kb]   (140 Downloads)    
Type of Study: Research | Subject: internal medicie
Received: 2016/06/23 | Accepted: 2017/02/18 | Published: 2018/04/8
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Talaei A, Rafiei N, Rafiei F, Chehrei A. The relation of TSH and depression in hypothyroid patients. J Shahrekord Univ Med Sci. 2018; 20 (1) :70-78
URL: http://journal.skums.ac.ir/article-1-2967-en.html

Volume 20, Issue 1 (4-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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