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:: Volume 19, Issue 2 (Jun, Jul 2017) ::
J Shahrekord Univ Med Sci 2017, 19(2): 32-40 Back to browse issues page
Fabrication of electrochemical sensor modified with nano graphene for determination of warfarin in plasma samples
Foroozan Hasanpour , Masoumeh Taei , Mohsen Nekoeinia , Bijan Dadras , Samira Divanzadeh
Chemistry Dept., Payame Noor University, PO BOX 19395-3697 Tehran, I.R. Iran , f.hasanpour@pnu.ac.ir
Abstract:   (1586 Views)

Background and aims: Warfarin is anticoagulant drug and prevents thromboembolism in cases such as pulmonary embolism and blood clot in a leg vein which under high risk of thrombosis. The therapeutic window of warfarin is very narrow. Therefore, it is important to monitoring the level of warfarin in blood patient. Electrochemical sensors are powerful tools in the field of diseases diagnosis and medical care, due to advantages such as high selectivity, high sensitivity and low. The aim of this study was fabrication of an electrochemical sensor base on modification of carbon electrode using graphene nanoparticle for quantification of warfarin in plasma.

Methods: In this study, plasma sample of 8 patients who had consumed warfarin were analyzed. After precipitation of plasma proteins by acetonitrile, the sample was centrifuged and the supernatant was transferred to a test tube. The resulting solution was evaporated by stream of nitrogen gas to complete drying. The dry residue was diluted by distilled water and transferred into the voltammetric cell for evaluation of warfarin oxidation by sensor.

Results: The results show that fabricated nano sensor strongly catalyzes the oxidation current of warfarin. Furthermore there are linear relationship (least squares method) between oxidation current of warfarin and its concentration in plasma.

Conclusion: The sensor as a simple, low-cost and accurate procedure is able to measure warfarin in patients' plasma.

Keywords: Warfarin, Electrochemical sensor, Graphen nano particles.
Full-Text [PDF 940 kb]   (848 Downloads)    
Type of Study: Research | Subject: pharmacology
Received: 2016/02/29 | Accepted: 2016/07/27 | Published: 2017/06/4
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Hasanpour F, Taei M, Nekoeinia M, Dadras B, Divanzadeh S. Fabrication of electrochemical sensor modified with nano graphene for determination of warfarin in plasma samples . J Shahrekord Univ Med Sci. 2017; 19 (2) :32-40
URL: http://journal.skums.ac.ir/article-1-2827-en.html

Volume 19, Issue 2 (Jun, Jul 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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