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:: Volume 17, Number 6 (suppl 2016) ::
J Shahrekord Univ Med Sci 2016, 17(6): 76-86 Back to browse issues page
Effect of hydroalcoholic extract of Matricaria chamomilla on passive avoidance memory and pain induced by global cerebral ischemia in Wistar rat
Mahbubeh Setorki, Azam Moshfegh *, Nasrin Raoufi
assiatant prof islamic azad u , moshfeghazam@gmail.com
Abstract:   (1483 Views)

Backgrounds and aims: Brain ischemia and reperfusion is a leading cause of serious and long- range disability in the world. The present study aimed to investigate the effect of hydroalcoholic extract of Matricaria chamomilla on memory impairments and pain induced by global cerebral ischemia.

Methods: Matricaria chamomilla flowers were purchased from herbal store and extracted with 70% alcohol. Animals were randomly divided into 6 groups of 7 rats. Control group received saline. Ischemia group underwent ischemia and received saline. Sham group underwent surgery without occlusion of carotid artery. Extract treated groups underwent ischemia and received M. chamomilla extract at doses of 50, 100, 200 mg/kg via ip injection. Behavioral test performed with shuttle box and analgesia test performed with tail flick test.

Results: Chamomile extract at doses of 50, 100 and 200 mg/kg significantly improved memory and learning impairments induced by ischemia. In addition, chamomile extract delayed the emergence of painful reflux in tail flick test. It showed better antinociceptive effect at 50 mg/kg.

Conclusion: Results of this study showed that chamomile extract possesses protective effects against ischemia induced pain and memory deficits that may be due to its anti-inflammatory and antioxidant effects.

Keywords: Keywords: Memory, Learning, Ischemia, Pain.
Full-Text [PDF 1091 kb]   (395 Downloads)    
Type of Study: Research | Subject: physiology
Received: 2016/01/6 | Accepted: 2016/01/26 | Published: 2016/03/10
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Setorki M, Moshfegh A, Raoufi N. Effect of hydroalcoholic extract of Matricaria chamomilla on passive avoidance memory and pain induced by global cerebral ischemia in Wistar rat. J Shahrekord Univ Med Sci. 2016; 17 (6) :76-86
URL: http://journal.skums.ac.ir/article-1-2754-en.html
Volume 17, Number 6 (suppl 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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