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:: Volume 20, Issue 1 (4-2018) ::
J Shahrekord Univ Med Sci 2018, 20(1): 22-35 Back to browse issues page
Use of lipophilic and hydrophilic polymers in production of sustained release zinc sulfate tablets
Naser Tavakoli , Abolfazl Mostafavi , Ahmad Movahedian attar , Mohammad Hossein Foroughi
Pharmaceutical Sciences Research Center, Pharmaceutics Dept., Isfahan University of Medical Sciences, Isfahan, I.R. Iran , mostafavi@pharm.mui.ac.ir
Abstract:   (710 Views)
Background and aims: Zinc sulfate administered to correct zinc deficiency. Its oral administration has shown serious digestive side effects and sometimes it has led to the lack of use it. The main aim of the present study was to use lipophilic and hydrophilic polymers in production of sustained release zinc sulfate tabletsover an extended period of time.
Methods: Sustained release (SR) zinc sulfate tablets were prepared using either lipophilic-based matrix or hydrophilic matrix system or natural polymers by either hot-fusion (HF) granulation or direct compression (DC) method. Physical and chemical features of provided SR tablets including hardness, friability, and weight variation, disintegration time, swelling index, content uniformity and drug release behavior were evaluated. The drug concentration was assayed by an atomic absorption spectrophotometer at 213.8 nm.
Results: Most of the prepared formulations showed acceptable physicochemical properties. Among 30 formulations, SR tablets with lipophilic matrix-based showed more predictable release profiles compared to tablets prepared based on hydrophilic or natural matrixes. Tablets containing carnauba wax showed slower release while tablets with hydrogenated castor oil represented faster release profile. A few lipophilic matrix tablets containing zinc sulfate
(110 mg), beeswax (or carnauba wax) and Avicel (or Emcompress) were selected as the optimum formulations showing release profiles based on USP criteria for lipophilic-based SR tablets. The mean dissolution time (MDT) and dissolution efficiency (DE8%) of selected formulations were 1.69-1.95 hr and 69.3-71.8%, respectively. Tablet hardness and granule size had no effects on release rate. The drug release kinetic followed Higuchi model.
Conclusion: Lipophilic based SR tablets of zinc sulfate is suggested as an alternative for capsule or syrup of the drug whichhave digestive side effects.
Keywords: Zinc sulfate, lipophilic matrix, hydrophilic matrix, sustained release tablets
Full-Text [PDF 1199 kb]   (144 Downloads)    
Type of Study: Research | Subject: pharmacology
Received: 2014/12/1 | Accepted: 2017/02/25 | Published: 2018/04/3
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Tavakoli N, Mostafavi A, Movahedian attar A, Foroughi M H. Use of lipophilic and hydrophilic polymers in production of sustained release zinc sulfate tablets. J Shahrekord Univ Med Sci. 2018; 20 (1) :22-35
URL: http://journal.skums.ac.ir/article-1-2250-en.html


Volume 20, Issue 1 (4-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
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