در حال انتقال سرور
   [Home ] [Archive]   [ فارسی ]  
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 15, Issue 5 (Dec,Jan 2013) ::
J Shahrekord Univ Med Sci 2013, 15(5): 97-110 Back to browse issues page
Association between cancer and serum adiponectin level: The review of epidemiologic evidences
Vajiheh Izadi , Leila Azadbakht *
Departmant of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Science, Isfahan, Iran , azadbakht@hlth.mui.ac.ir
Abstract:   (7673 Views)
Background and aims: Adiponectin, an adipose tissue derived adipokines, have anti- inflammatory, anti- obesity and anti- diabetic properties. There are several studies inrestigated the association between this hormone and different types of cancer. In present study, we aimed to review the relationship between adiponectin and cancers. Methods: In this review study, various articles as following: case conlral, cross sectional and longifudinal study have been found through PubMed search engine from 2002 to October 2011, by using the following key words: cancer, malignancy, cell proliferation and adiponectin. Finding: From the total number of 45 articles evidences proved the inverse association between the hormone and the risk of breast cancer, in which has been shown both cohort and case-control studies, in pre- and post- menopausal women. Endometrial cancer risk was significantly lower in women with higher plasma adiponectin level compared to women with lower level of hormone. Risk of benign prostate hyperplasia (BPH) and prostate cancer were higher in men with lower level of adiponectin concentration. Studies have shown the inverse correlation between the mentioned hormone and risk of colorectal cancer. Also, it seems that adiponectin inversely associates with pancreatic cancer in men. Conclusion: It seems that serum adiponectin level have inversly associated with risk of several cancers. This hormone suppresses the growth and proliferation of cancer cells, direct or indirect, via several mechanisms.
Keywords: : Cancer, malignancy, cell proliferation, adiponectin
Full-Text [PDF 235 kb]   (3687 Downloads)    
Type of Study: Review article | Subject: internal medicie
Received: 2012/06/22 | Accepted: 2013/11/3 | Published: 2013/11/3
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Izadi V, Azadbakht L. Association between cancer and serum adiponectin level: The review of epidemiologic evidences. J Shahrekord Univ Med Sci. 2013; 15 (5) :97-110
URL: http://journal.skums.ac.ir/article-1-1142-en.html


Volume 15, Issue 5 (Dec,Jan 2013) Back to browse issues page
مجله دانشگاه علوم پزشکی شهرکرد Journal of Shahrekord University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3792